Macrophage Gene Expression and Foam Cell Formation is Regulated by Plasminogen Running title :

Macrophage Gene Expression and Foam Cell Formation is Regulated by Plasminogen Running

Macrophage gene expression and foam cell formation are regulated by plasminogen.

BACKGROUND Deciphering the molecular and cellular processes that govern macrophage foam cell formation is critical to understanding the basic mechanisms underlying atherosclerosis and other vascular pathologies. METHODS AND RESULTS Here, we identify a pivotal role of plasminogen (Plg) in regulating foam cell formation. Deficiency of Plg inhibited macrophage cholesterol accumulation on exposur...

Compare the Effect of Eicosapentaenoic Acid and Oxidized Low-Density Lipoprotein on the Expression of CD36 and Peroxisome Proliferator-Activated Receptor Gamma

Background: There is evidence that CD36 promotes foam cell formation through internalizing oxidized LDL (ox-LDL) into macrophages therefore, it plays a key role in pathogenesis of atherosclerosis. In addition, CD36 expression seems to be mediated by nuclear receptor peroxisome proliferator-activated receptor gamma (PPAR-γ). The aim of the present study was to evaluate and compare the effect of ...

Inhibitory effect of Cinnamon on prevention of foam cell formation in platelet and monocytes co-culture

Introduction: Atherosclerosis is one of the leading causes of cardiovascular disease. Following endothelial damage and platelet aggregation in that area and the recruitment of monocytes and their conversion to macrophages, LDL gradually accumulates under the endothelial artery wall and gradually oxidized and convert to oxi-LDL. By swallowing it, the macrophages turn into foam cell and then athe...

Plasmin promotes foam cell formation by increasing macrophage catabolism of aggregated low-density lipoprotein.

OBJECTIVE The plasmin/plasminogen system is involved in atherosclerosis. However, the mechanisms by which it stimulates disease are not fully defined. A key event in atherogenesis is the deposition of low-density lipoprotein (LDL) on arterial walls where it is modified, aggregated, and retained. Macrophages are recruited to clear the lipoproteins, and they become foam cells. The goal of this st...